{"id":450,"date":"2014-05-07T23:32:26","date_gmt":"2014-05-07T23:32:26","guid":{"rendered":"http:\/\/discoveryrehab.com\/?page_id=450"},"modified":"2018-03-30T17:42:30","modified_gmt":"2018-03-30T17:42:30","slug":"20-things-to-know-about-pristiq-desvenlafaxine","status":"publish","type":"page","link":"https:\/\/discoveryrehab.com\/20-things-to-know-about-pristiq-desvenlafaxine\/","title":{"rendered":"20 Important Pristiq Facts You Need to Know About (Desvenlafaxine)"},"content":{"rendered":"
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[adsense_inserter id=”484″]<\/p>\n
Pristiq’s strength lies in it’s ability mainly to alter mood.<\/p>\n
Specifically it is used as a?serotonin?norepinephrine reuptake inhibitors (SNRIs).<\/p>\n
It is considered an antidepressant medication is most often used in the treatment of major depression and other mood disorders.<\/p>\n
It is also sometimes used to treat anxiety disorders, obsessive-compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), chronic neuropathic pain, and fibromyalgia syndrome (FMS), and for the relief of menopausal symptoms.<\/p>\n
14.) Your surgeon or anesthesiologist needs to know that you are taking Pristiq.?<\/b>if you are having any type of surgery, including oral or dental surgery.<\/p>\n
15.) Pristiq may cause false changes in laboratory tests<\/b>, False-positive urine immunoassay screening tests for phencyclidine (PCP) and amphetamine have been reported in patients taking desvenlafaxine. This is due to lack of specificity of the screening tests. False positive test results may be expected for several days following discontinuation of desvenlafaxine therapy.<\/p>\n
16.)<\/b>?People taking Pristiq may have elevated Blood Pressure.<\/b>?Patients receiving this medication should have regular monitoring of blood pressure since increases in blood pressure were observed in clinical studies.<\/p>\n
17.) Avoid drinking grapefruit juice when taking this medication?<\/b>as it?can lead to deleterious interactions.<\/p>\n
18.) This drug will not cure mood disorders, anxiety or depression<\/b>. But it will help control the behavior that accompanies these conditions.It usually takes several weeks of antidepressant therapy before they will start to feel better. Do not to stop taking the drug if you do not feel the results right away.<\/p>\n
19.) If you have or have ever had<\/b>?heart disease, diabetes, heart failure, irregular heartbeat, stroke, or seizures you should talk to your doctor about these conditions before you take Pristiq. Desvenlafaxine?may interact with other medications or supplements, including antihistamines, antidepressants, anti-fungal, sleeping pills, HIV medications, high blood pressure medications, and more.<\/p>\n
20.) What is the?half-life of Pristiq?<\/b>?Approximately 45% of a single oral dose is eliminated unchanged in urine at 72 hours; approximately 19% of the dose is excreted as the glucuronide metabolite and less than 5% is excreted as the oxidative metabolite (N, O-didesmethylvenlafaxine) in urine. Mean elimination half-life is approximately 11 hours.<\/p>\n2.) Pristiq?<\/b>works by leveling out certain neurotransmitters<\/b><\/h2>\n
The imbalance among neurotransmitters (norepinephrine, serotonin, and dopamine) is the cause of depression.<\/p>\n
Pristiq prevents the reuptake of serotonin and epinephrine after they have been released (delaying the breaking down and recycling of these neurotransmitters).<\/p>\n
So, reduced uptake causes a prolonged effect of serotonin and norepinephrine in the brain.<\/p>\n
Pristiq is approximately ten times more potent at inhibiting serotonin uptake than norepinephrine uptake.<\/p>\n
This makes it a markedly more effective alternative with lesser drug interactions than standard antidepressants.<\/p>\n
Pristiq could generate more than $2 billion of annual sales?<\/b>analysts predicted.<\/p>\n
A federal judge granted class-action status to former Wyeth Inc. shareholders who accused the company of misleading them about risks associated with the antidepressant Pristiq.<\/p>\n
Wyeth shares lost more than $7.6 billion of market value after U.S. Food and Drug Administration received information about potential serious heart and liver problems associated with use of the drug. <\/b>Pfizer bought Wyeth in 2009. <\/b><\/p>\n
Pfizer reported $577 million in revenue from Pristiq in 2011.<\/b><\/p>\nIf you?re new to Pristiq you likely have some questions about the drug. So let?s dive into the most important information about this drug.<\/h1>\n
There are a lot of people that use this drug that deserve to understand it better.<\/p>\n
Everyone deserves to understand it better.<\/p>\n
Let’s help you understand.<\/p>\n
Primary use of Pristiq in medicine is in the treatment of major depressive disorder<\/b><\/p>\n
Normal dose is <\/b>50 mg PO once daily<\/p>\n
Higher dosages, up to 400 mg\/day, have been used but have not been proved to be better. And increased side effects have been reported.<\/p>\n
Assess periodically to determine need for continued treatment.<\/p>\n
For Renal impaired patients<\/span><\/strong><\/p>\n For Hepatic impaired patient<\/span><\/strong><\/p>\n Take whole with fluid; do not divide, crush, chew, or dissolve<\/p>\n Take at approximately the same time every day<\/p>\n NOTE: Safety and efficacy not established in Pediatric<\/p>\n The amount of this medication needed to result in an overdose?<\/b>greatly depends on the individual characteristics of the user.<\/p>\n Body weight, length of use and individual brain chemical balances all factors in.<\/p>\n Among the patients included in the major depressive disorder trials of Pristiq, there were four adults who ingested doses greater than 800 mg of desvenlafaxine (4000 mg [desvenlafaxine alone], 900, 1800 mg and 5200 mg [in combination with other drugs]); all patients recovered.<\/p>\n In addition, a patient?s 11-month-old child accidentally ingested 600 mg of desvenlafaxine, was treated and recovered.<\/p>\n Yes, death has been reported with high dosage Pristiq is known to cause death when consumed in excess.<\/p>\n Overdoing a desvenlafaxine medication often results in?serotonin syndrome for the user.<\/p>\n The effects of this syndrome range from mild irritability and accelerated heart rate all the way to fatality. It depends on how much of an overdose it is.<\/p>\n In the event of an expected overdose, you or your loved ones should take immediate action and seek medical help.<\/b><\/p>\n Any?noticeable negative side effect is cause for a medical consultation. These and other symptoms might be signs of an allergy, incompatible venlafaxine drug interactions, or other complications and should be addressed as soon as possible.?<\/span><\/p>\n If the overdose was recent, a healthcare provider may give certain medicines or place a tube into the stomach to ?pump the stomach?.<\/p>\n However, once desvenlafaxine has been absorbed into the body, there is no treatment that can remove it quickly as no specific antidotes are known. In managing overdosage, the possibility of multiple drugs is considered.?In these cases, treatment must revolve around supportive care in addressing the symptoms that occur as a result of the overdose. For example, supportive treatment options may include:<\/p>\n a.) Adverse drug reactions (ADRs)<\/b> shown occur with 50 mg\/day dosage at rate higher than seen with placebo:<\/p>\n Very common Side effects (>10% incidence)?<\/b><\/p>\n Less Common Side effects (1-10% incidence)?<\/b><\/p>\n Frequency of following side effects is not defined<\/b><\/p>\n b.) Contraindications<\/b><\/p>\n Yep, it can. And it often does.<\/p>\n Many people complain about Pristiq making them feel too sleepy to function well.<\/p>\n Pristiq and drowsiness are often known to come together.?<\/b><\/p>\n It?s just the nature of this medication to affect parts of the brain which dictate feelings of energy and awareness.?Pristiq can make you extremely drowsy. So know the risks.<\/p>\n These side effects can include dizziness, drowsiness, and difficulty concentrating.<\/p>\n Some people may also experience impairment in thinking and judgment.<\/p>\n You should avoid or limit the use of alcohol while being treated with desvenlafaxine.<\/p>\n Do not use more than the recommended dose of desvenlafaxine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you.<\/p>\n a.)<\/b>?For some people it is great at reducing anxiety symptoms associated with depression.?<\/b>Researchers at Wyeth, a company of the Pfizer Group, found in short-term, double-blind, placebo-controlled trials that desvenlafaxine was associated with significantly greater improvement in anxiety symptoms compared with placebo in patients with MDD.<\/p>\n But?<\/p>\n b.) Many others experience new or increased depression from prescribed doses of<\/b>?Pristiq<\/b>. This is not uncommon. While some people respond well to the changes in their life caused by Pristiq, the downsides to the drug just don?t mesh well with others.<\/p>\n Pristiq can be great for depression, but if it?s tiring you out and making you feel weak enough that you need an amphetamine just to feel like anything other than apathy, you might want to shop around.<\/p>\n Some young people have thoughts about suicide when taking medicine for a major depressive disorder and other psychiatric disorders.<\/p>\n Your doctor will need to check your progress at regular visits while you are using Pristiq. Your family or other caregivers should also be alert to changes in your mood or symptoms.<\/p>\n 9.) Pristiq Drug Interactions<\/b><\/p>\n Drug interactions may change how your medications work or increase your risk for serious side effects. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.<\/p>\n Some products that may interact with this drug include:<\/p>\n 10.) Pristiq Black Box Warnings<\/b><\/p>\n Antidepressants increase risk of suicidal thinking<\/b> and behavior in children, adolescents, and young adults (18-24 years) in short-term studies. Increased risk not observed in patients >24 years; slight decrease observed in patients >65 years.<\/p>\n In children and young adults, initiate only if benefits greatly outweigh risks. Monitor closely for changes in behavior, clinical worsening, and suicidal tendencies during initial 1-2 months of therapy and dosage adjustments<\/p>\n Patient?s family should communicate any abrupt behavioral changes to healthcare provider<\/p>\n Worsening behavior and suicidal tendencies that are not part of presenting symptoms may necessitate discontinuance of therapy<\/p>\n Not approved for use in pediatric patients<\/p>\n 11.) What?s more common with Pristiq? weight loss or weight gain??<\/b><\/p>\n The answer to this question is that it varies.<\/b>?Weight gain is an increase in body weight. This can be either an increase in muscle mass, fat deposits, or excess fluids such as water. Everybody is different and every reaction to drugs has its own unique flavor. Some people gain weight, some people lose weight, and for others their weight remains neutral. While it doesn’t happen often, people taking Pristiq can gain weight. However, it is actually more likely for a person to lose weight while taking this antidepressant. If weight gain becomes a problem for you during treatment, consult your doctor. He or she can make sure this isn’t being caused by another condition and, if necessary, can switch you to another medication.<\/p>\n a.) Pristiq related weight loss<\/b><\/p>\n b.) Pristiq related weight gain<\/b><\/p>\n 12.) Withdrawals from Pristiq<\/b><\/p>\n (NOTE: Do not reduce or stop your regimen without the doctor?s approval and oversight)<\/p>\n Discontinuation symptoms<\/b> have been systematically and prospectively evaluated in patients treated with Pristiq during clinical studies in Major Depressive Disorder. Abrupt discontinuation or dose reduction has been associated with the appearance of new symptoms that include dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesia, such as electric shock sensations), anxiety, confusion, headache, lethargy, emotional liability, insomnia, hypomania, tinnitus, and seizures. While these events are generally self-limiting, there have been reports of serious discontinuation symptoms.<\/p>\n 13.) Pristiq and Pregnancy<\/b><\/p>\n a.) Pristiq is pregnancy category <\/b>C<\/b><\/span> drug. <\/b>If you are pregnant or become pregnant while taking Pristiq, you should talk to your doctor about alternative treatments for your condition. Pristiq can cause problems in newborns if taken during pregnancy or while breastfeeding.<\/p>\n Possible complications, sometimes severe and requiring prolonged hospitalization, respiratory support, enteral nutrition, and other forms of supportive care in neonates exposed to SNRIs or SSRIs late in the third trimester; may arise immediately upon delivery.<\/p>\n Carefully consider the potential risks and benefits of treatment when used during the third trimester of pregnancy. Consider cautiously tapering dosage during the third trimester prior to delivery.<\/p>\n b.) Nursing while on this drug is not recommended.<\/b>?Small amounts of the drug are known to be distributed in breast milk. The manufacturers of the drug advise abstaining during nursing.<\/p>\n About Pristiq?<\/sup> ER<\/b><\/p>\n The active ingredients in regular tablets are usually released within 15 to 30 minutes of when they are ingested.? Often they are prescribed to be taken three or four times a day.? The active ingredients in extended-release tablets are released over a much longer period of time and are usually taken only once or twice a day.<\/p>\n Pricing Information:<\/b><\/p>\n 30-tabs\/$152.99 and 90-tabs\/$439.99<\/p>\n 30-tabs \/$150.98 or 90-tabs\/$429.97<\/p>\n This pricing information was updated 02\/2014. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.<\/p>\n Manufacturer:<\/b><\/p>\n Wyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.<\/p>\n Inactive ingredients:?<\/b><\/p>\n Instructions for consumer<\/b><\/p>\n \n Sources<\/b><\/p>\n [adsense_inserter id=”484″] 1.) What is Pristiq? Why is it used? Pristiq’s strength lies in it’s ability mainly to alter mood. Specifically it is used as a?serotonin?norepinephrine reuptake inhibitors (SNRIs). It is considered an antidepressant medication is most often used in the treatment of major depression and other mood disorders. It is also sometimes used to …<\/p>\n\n
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Best Practices for Administration<\/h2>\n
5.) Can you Overdose on Pristiq?<\/b><\/h2>\n
Symptoms that might indicate an overdose has?occurred?include:<\/h3>\n
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Can an overdose of Pristiq result in death??<\/b><\/h2>\n
Management of Overdose?will vary.<\/h3>\n
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6.) Associated Side effects and Risks<\/h2>\n
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7.) Can Pristiq Cause People to Feel Sleepy or Drowsy?<\/h2>\n
Using Pristiq together with alcohol can increase nervous system side effects<\/h3>\n
8.) Pristiq and Anxiety<\/h2>\n
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