{"id":362,"date":"2018-08-19T01:26:43","date_gmt":"2018-08-19T01:26:43","guid":{"rendered":"http:\/\/discoveryrehab.com\/?page_id=362"},"modified":"2018-08-21T03:29:39","modified_gmt":"2018-08-21T03:29:39","slug":"19-things-to-know-about-seroquel-quetiapine-fumarate","status":"publish","type":"page","link":"https:\/\/discoveryrehab.com\/19-things-to-know-about-seroquel-quetiapine-fumarate\/","title":{"rendered":"19 Important Seroquel Facts You Need to Know (Quetiapine Fumarate)"},"content":{"rendered":"
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Seroquel is an oral atypical antipsychotic drug that the FDA approved the use of in September 1997. <\/span><\/p>\n A single?25mg dose is the smallest tablet made and 400mg is the greatest.<\/span><\/p>\n <\/p>\n Quetiapine is used alone or in combination with other drugs to treat schizophrenia and bipolar disorder.<\/span><\/p>\n It’s intended for bipolar disorder (manic depression) in adults and children who are at least 10 years old. It is also used together with antidepressant medications to treat a major depressive disorder in adults.<\/span><\/p>\n It also prescribed for treating major depression?in combination with antidepressants and to treat schizophrenia in adults and children who are at least 13 years old.\u00a0<\/span><\/p>\n The efficacy of Seroquel in schizophrenia was established in three 6-week trials in adults and one 6-week trial in adolescents (13-17 years). <\/span><\/p>\n The effectiveness of Seroquel for the maintenance treatment of schizophrenia has not been systematically evaluated in controlled clinical trials<\/strong><\/span><\/p>\n It’s sedating in low dose, 100mg and lower is said to be more sedating. There are a lot of people these days who are prescribed take it just for sleep.\u00a0<\/strong>More on that later.<\/span><\/p>\n It’s said that you will sleep with no disturbance (although the effects of the sleep cycle are unknown). <\/span><\/p>\n It’s also been used to treat Alzheimer’s patients, although it’s not licensed to treat this.<\/span><\/p>\n What does the medication Seroquel do exactly? <\/span><\/p>\n How does it treat severe mental illnesses?<\/span><\/p>\n Although the mechanism of action of quetiapine is unknown, like other antipsychotics, it inhibits communication between nerves of the brain. <\/span><\/p>\n It does this by blocking receptors on the nerves for several neurotransmitters,<\/strong> the chemicals that nerves use to communicate with each other. <\/span><\/p>\n It is thought that its beneficial effect is due to blocking of the dopamine type 2 (D2) and serotonin type 2 (5-HT2) receptors.<\/span><\/p>\n This is why it works for bipolar disorder, effectively quieting the mind<\/strong> and helping with the manic side of this illness. <\/span><\/p>\n It can help to manage or mitigate the racing thoughts, obsessive thoughts, suicidal thoughts. Paranoia, hallucinations, psychomotor excitation, delusions.<\/span><\/p>\n <\/p>\n Use for insomnia & anxiety is “off-label” (<\/strong>meaning that it is not strictly approved for use in these cases).<\/span><\/p>\n Because of this, there are no official guidelines for dose and correct usage.<\/span><\/p>\n However, in practice it’s common for 50 – 100mg to be prescribed once at night to help with insomnia.?<\/strong><\/span><\/p>\n This is the typical range, but under some circumstances upwards of 200mg doses are prescribed.<\/span><\/p>\n It’s important to note that many doctors do not recommend prescribing quetiapine for sleep disturbance.<\/strong> <\/span><\/p>\n This is because of its powerful use as an atypical antipsychotic.?Zolpidem,?zopiclone, eszopiclone (Z-drugs\/non-benzos)<\/strong> are often better at inducing sleep due to their being hypnotics, and without as much as “brain dampening” side effects compared to Seroquel.<\/span><\/p>\n But, others argue that at the low dosages needed to promote sleep<\/strong> (typically <200mg), that Seroquel is not strong enough to provide it’s antipsychotic effects and only acts as a powerful anti-histamine\/sleep inducer.<\/span><\/p>\n But the question remains concerning any of these drugs as good long-term solutions for sleep problems. <\/span><\/p>\n Short-term use can be okay, but eventually, tolerance will rise, effectiveness will decrease and dependence will occur<\/strong>. <\/span><\/p>\n Drugs can only mask deeper psychological complexes, and one must directly work with the roots of their suffering if they want any lasting change.<\/span><\/p>\n <\/p>\n For some people, yes. Oddly enough abuse of antipsychotic medications is a real thing.<\/span><\/p>\n Seroquel has a psychotropic\u00a0effect, maybe not one you would like or classify recreational but it does. <\/span><\/p>\n Its a major sedative\/anti-psychotic and will most likely lead to sedation and drowsiness.<\/span><\/p>\n It can cause that slight dissociation effect which some people enjoy. <\/span><\/p>\n I’ve read that some individuals supplement any and all of their psychedelic trips with Seroquel and end every stimulant trip with Seroquel.<\/span><\/p>\n One user said:<\/span><\/p>\n Now with that said,<\/span><\/p>\n Seroquel can be a dangerous drug.<\/strong> Is it a very bad idea\u00a0<\/em>to mix it with other stuff, that could end really bad.<\/span><\/p>\n Do not ever take ever Seroquel with DXM.<\/strong>?Also, Seroquel taken with opiates is more dangerous than taking benzos simultaneously with opiates, so avoid that too. You’ll also likely end up in the?ER for a few hours after mixing it with coke.<\/span><\/p>\n Just heard of someone else on the news going to the ER after taking Seroquel with opiates. It’s a great med for withdrawals cause you’ll sleep. It’s great for its prescribed purposes. But don’t take it if your on drugs or even if you’re already coming down or you could lose your life.<\/span><\/p>\n You can definitely overdose on this drug when used recreationally or in excess. So be careful.<\/span><\/p>\n Too much Seroquel can cause seizures though isn’t that part of od-ing.<\/span><\/p>\n The seizures are due to hypokalemia (a considerable loss of potassium or lowering of potassium in the blood serum.)<\/span><\/p>\n 600 to 1000mg (depends on body weight) would be the highest dose many recreational users suggest; but not unless you are accustomed to the medication (take it on a usual basis). <\/span><\/p>\n But remember, recreation use should never be suggested anyway!\u00a0<\/strong>And these upper limits might not be what you could handle, everybody is different.<\/span><\/p>\n If you use it as a sedative to come down from a stimulant experience or possibly help with a negative psychedelic experience there is no need to exceed (200mg)<\/span><\/p>\n Remember, tolerance to Seroquel is built up real fast. As far as recreational use goes, too much of it can cause anxiety flairs up, shadows constantly shift around, and voices start materializing.<\/span><\/p>\n Some users choose to insufflate the drug.<\/span><\/p>\n Insufflating antipsychotics generally does not yield a higher bioavailability,\u00a0but it is important to look the oral bioavailability up before trying this.<\/b><\/span><\/p>\n However, one can do this at home to have symptoms relieved in 2 minutes or so. <\/span><\/p>\n That is a big deal considering many antipsychotics take 45 minutes to work orally.<\/span><\/p>\n But no, snorting is really not a good idea.<\/span><\/p>\n <\/p>\n Yes, you can overdose on Seroquel. And it can be fatal.<\/p>\n After a massive overdose of quetiapine, fatal consequences can be delayed up to 50 hours after ingestion, if not beyond.<\/strong><\/span><\/p>\n Therefore, these patients require prolonged observation in a monitored or intensive care setting.<\/span><\/p>\n Seroquel overdose symptoms<\/strong> include:<\/span><\/p>\n For Seroquel overdose treatment, the individual who overdosed, or a family member or anyone who finds an individual in this compromised state should call for medical help immediately and get the individual to a hospital ER as soon as possible.<\/strong><\/span><\/p>\n Both Seroquel and alcohol affect the body in a sedative way. <\/span><\/p>\n When mixed, the results can be powerful.<\/strong><\/span><\/p>\n Standard scenario of drinking while on atypical antipsychotics is dehydration that increases side effects, heavy sedation from the drug’s interactions, a need for a lot of sleep and a hangover that consists of a nice headache and cloudy feeling the next day.<\/strong><\/span><\/p>\n Worse interactions, often following an overdose, can place you in the ICU for days.<\/strong> Seizures are a possibility, as is injuring oneself. Heavy emotions like severe depression and mania can also occur.<\/span><\/p>\n The general advice is to drink in moderation if you do choose to drink.\u00a0<\/strong>(Even better, just give up on drinking.) <\/span><\/p>\n Many people find that their alcohol tolerance decreases <\/strong>once on APs (anti-psychotics) and one to three beers will really be all it takes to get them sufficiently drunk.<\/span><\/p>\n But beware; many people report blacking out without having the usual warning signs of being too drunk. <\/span><\/p>\n You might go from only feeling slightly tipsy to waking up the next morning wondering what the hell happened.<\/strong><\/span><\/p>\n Remember that you are posing an increased risk of long-term brain damage from these drugs by combining them. There is still not much known about their long-term effects (or even short-term, for that matter).<\/strong><\/span><\/p>\n If you love beer, just drink alcohol-free beer. \ud83d\ude42<\/span><\/p>\n <\/p>\n The withdrawals from this drug can be very uncomfortable, agitating and draining.<\/span><\/p>\n Many people who used Seroquel to sleep might experience even worse insomnia than what they had before starting Seroquel. <\/span><\/p>\n This can last for weeks.<\/span><\/p>\n Often times people report not feeling like themselves for a long time after stopping or starting to taper off Seroquel. <\/span><\/p>\n And this is often accompanied by a general sick feeling, sudden temperature changes, shooting “zapping” sensations in their head and severe emotional distress.<\/span><\/p>\n How long do the withdrawal effects last for?<\/strong><\/span><\/p>\n Rare but serious side effects have been reported with this kind of medicine that can persist even after stopping the drug.<\/span><\/p>\n A neurological disorder known as NMS or Neuroleptic Malignant Syndrome might occur. NMS is characterized by muscle rigidity and fever. <\/span><\/p>\n Another serious side effect that has been reported is Tardive Dyskinesia (uncontrollable movements and twitching, mostly in the face, but can occur elsewhere in the body. <\/span><\/p>\n This can entail body twitching that happens every few seconds of every day. And sadly, some cases persist for years after stopping the drug.<\/span><\/p>\n The worst part of stopping Seroquel ‘cold turkey’ is the first 48-72 hours; chills, sweats, anxiety…much like stopping any neuroleptic. Because of this, it is recommended to slowly taper. Ask your doctor about tapering effectively.<\/span><\/p>\n Immediate release quetiapine usually is taken two or three times daily. Extended-release quetiapine is taken once daily.<\/strong> The dose usually is increased slowly over several days or weeks to achieve the desired effect. Quetiapine can be taken with or without food, although you will feel the effects quicker and more strongly when on an empty stomach.<\/span><\/p>\n The (typical) initial dose for bipolar disorder<\/b>?is 50 mg twice daily (100 mg\/day) of immediate release quetiapine. The dose can be increased by 100 mg\/day to a daily dose of 400 mg\/day. Most patients respond to 400-800 mg\/day. Doses greater than 800 mg\/d have not been studied. The starting dose is 300 mg once daily and the target dose is 400-800 mg once daily when using extended-release tablets.<\/span><\/p>\n The (typical) initial dose for schizophrenia\u00a0<\/b>is 25 mg twice daily (50 mg\/day) of immediate-release tablets. The dose can be increased by 25-50 mg two or three times daily. The target dose is 300-400 mg\/day in two or three doses. Patients respond to 150-750 mg\/day and doses greater than 800 mg\/day have not been evaluated. The starting dose is 300 mg once daily and the target dose is 400-800 mg once daily when using extended-release tablets.<\/span><\/p>\n The dose range for treating major depression\u00a0<\/b>is 150-300 mg\/day of extended-release tablets. The starting dose is 50 mg in the evening for 2 days increasing to 150 mg in the evening.<\/span><\/p>\n The XR pills<\/strong> (extended release) come in these dosages:<\/span><\/p>\n2.) What is Seroquel Used For?<\/strong><\/span><\/h2>\n
3.) How Does Seroquel Work?<\/strong><\/span><\/h2>\n
4.) Seroquel for Sleep: is Quetiapine Fumarate an Effective Sleep Aid? \/ Insomnia<\/strong><\/span><\/h2>\n
5.) Does Seroquel Have Any Recreational Value?<\/strong><\/span><\/h2>\n
Is there a noticeable Seroquel “high”?<\/span><\/h3>\n
“If you are someone who occasionally has a night of cocaine abuse, taking Seroquel shortly after you stop using is a great way to avoid the often times harsh comedown. It’s also a great way to get a good night of rest after serious drinking and possibly sleep through a morning hangover.”<\/em><\/span><\/h2>\n
6.) What is the Typical Recreational Dose of Seroquel?<\/span><\/strong><\/h2>\n
How about snorting Seroquel?<\/span><\/h3>\n
7.) Can you Overdose on Seroquel?<\/strong><\/span><\/h2>\n
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8.) How Does Seroquel Interact with Alcohol? Is it Safe?<\/strong><\/span><\/h2>\n
9.) What are Seroquel Withdrawals Like?<\/strong><\/span><\/h2>\n
10.) What is the Standard Dosage for Seroquel?<\/strong><\/span><\/h2>\n
11.) What about Seroquel XR Extended Release?<\/strong><\/span><\/h2>\n
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